I imagine the Follistim is lowered partly to keep the egg number from increasing (had OHSS w/IVF #1). I had success on an EPP. I used two patches a dayandchanged the patches every third day. 1) focus on the quality (not quantity) of eggs. Estrogen is administered during the luteal phase of the previous menstrual cycle to "prime" the FSH receptors which enhances the response to FSH. As you can see below, success rates dropped. You may wonder how thats possible. I'm struggling not to blame myself as my husband's swimmers are per. . What to Expect supports Group Black and its mission to increase greater diversity in media voices and media ownership. This website uses cookies for functionality, analytics and advertising purposes as described in our, http://www.fertstert.org/article/S0015-0282. Estrogen priming is a protocol used during in vitro fertilization (IVF) to facilitate a more gradual and coordinated growth of follicles in the ovary in women with diminished ovarian reserve (DOR). Is a micro-dose lupron protocol considered a low-dose protocol? maternal age" i.e. The meds alone cost $5,400. ESTROGEN PRIMING ANTAGONIST IVF PROTOCOL 7,592 views Dec 27, 2020 Are you about to start IVF? it's 1 week since last patch. Check out this video to learn more about the. Estrogen Priming Protocol: In some women who respond poorly to the short protocol (e.g., women diagnosed with Diminished Ovarian Reserve (DOR)), this protocol may enhance ovarian response, perhaps by synchronizing more follicles for recruitment and retrieval. Weill Cornell Medical Center, Division Chief After 2 years, tons of tests and 5 IVF cycles, it still feels unreal.Estrogen Priming protocol does not have birth control pills. I hope your's goes lots better than mine! Just not sure what type of protocol would be best. i had success with DE. Here's what you need to know about the project. Thanks for well wishes. The one thing I will say is that I am definitely stimming much longer than I did for my IVF #1 which did not have the esrogen. Estrogen priming refers to supplementing women with extra estrogen (estradiol) during the luteal phase - that's the last two weeks - of the prior menstrual cycle before beginning ovarian hyper-stimulation for IVF. Still seems to have had plenty of effect though. Any success stories for low responders of Estrogen Priming cycle? Once you surge (and presumably ovulate) you count 10 days from the surge. Advertising Policy -
A fundamental question is whether protocols using a lower dose of gonadotropins do as well as those using a higher dose of gonadotropins. This is my first time posting and was hoping for some other stories like mine. Search I know this is old but was your period seriously delayed after estradiol patch? Is estrogen priming the same thing as using BCPs to suppress? Of course, during a regular cycle most women naturally produce only a single mature egg. Around 50-60% of couples find success with IUI after 5 cycles, which is about a 10-20% success rate per cycle. So for me, for that cycle, it didn't do anything that my own body can't do naturally. Are you sure you want to block this member? This protocol is used almost exclusively in women whove had a poor response in a previous cycle or who have evidence of diminished ovarian reserve (AMH less than 0.5 or an AFC less than 5). IVF #1, we did Follistim, Menopur, Cetrotide. Hi. Do they use this protocol as sort of standard for someone who is starting? This is the oldest IVF protocol and is especially effective in preventing premature ovulation during the cycle. I started my estrace this morning and feel a little icky so far. I have had 4 failed ivf cycles on the short antagonist protocol which all failed, 3 out of the 4 cycles I had 1 average embryo which resulted in chemical pregnancies and 1 cycle I had nothing to. Thanks for sharing. Looking for info/success stories with Estrogen priming protocol with DOR. Time is of the essence and whatever information we have, we are happy to share to help you! Did not cover diagnostics like doppler test (40 copay but insurance might have covered this), communicable testing ($400 per person), and specialty meds . Hey Michelle, I haven't forgotten about you. Or are there different levels of this? After being on BCPs for so long, it took a long time for my period to come back (it's been 5 years though now), but my cycle has still never been the same so I'm wary of BCPs. unfortunately, it was just an age issue, which i knew all along, but i had to try. This is done by administering estrogen, typically via an estrogen patch or an injection, sometimes along with additional Gonadotropin-releasing hormone. This is not recommended for shared computers. Dwarf Mr Snow, Fred's Tie Dye, Saucy Mary, Sweet Scarlet, Kangaroo Paw Green, Idaho Gem and Banana Toes are just a few of the varieties one gardener is growing in a 4x8 bed of "bulletproof" tomatoes. Ramped up to cycle on BCP for two weeks and Lupron 10 units 2x/day on stims. Outdoor sports and activities of all types. I was on BCP for 20 years (have been off for several now) and it took me a long time to normalize after coming off them. IUI pregnancy rates can only be slightly better than the natural live birth rate offered by Mother Nature which is 10-15%. Estrogen is administered during the luteal phase of the previous menstrual cycle to "prime" the FSH receptors which enhances the response to FSH. I also did ganirelix during this time. Group Black's collective includes Essence, The Shade Room and Naturally Curly. You can see my sig. A Group Leader is a What to Expect community member who has been selected by our staff to help maintain a positive, supportive tone within a group. Ganirelix is contraindicated in pregnancy. I dont know as much about micro flare. Please enable JavaScript in your browser to load the challenge. While gonadotropin is the critical drug in most every protocol, its not the only drug. It would be great if it cleared up my skin because my skin has been terrible since my retrieval/chemical a few weeks ago! I think you both are at Cornell (were) with this estrogen priming protocol will you try again with them, and request not to do estrogen priming? In that time a womans hormonal balance has been restored and so IVF cycles using a frozen transfer are more likely to work. But not all patients respond equally to ovarian stimulation using these hormones. On the other hand, if too much gonadotropin is taken, a woman is at higher risk of hyperstimulation, known as Ovarian Hyperstimulation Syndrome or OHSS. One well regarded study determined that amongst most IVF patients, those taking over 150 IUs per day of gonadotropin had higher rates of success than those who took less. Froze 3. - Baseline u/s and b/w. May I ask what your AMH was? I also did estrogen priming with the mini. Thanks so much! A gonadotropin-releasing antagonist hormone (GnRH-ant) is used to stop the ovaries from releasing the matured eggs and allows time for additional maturation until eggs are retrieved for fertilization. Estrogen priming also allows the patient and clinicians to schedule the ovarian stimulation cycle and the timing of egg retrieval. However other had mature egg and we did Icsi by it didn't grow from there. Sign up now for your monthly dose of fertility info, experiences, and insight. It is used on lowish amh patients and those who respond poorly to drugs which affect their lining. Estrogen priming through luteal phase and stimulation phase improved ovarian responsiveness and this may lead to an increase in pregnancy rate in poor responders with failed cycle. I have AMH of 0.1 or something like that. As you can see below, amongst women with PCOS, the Antagonist protocol drives comparable success rates but with far lower risk of hyperstimulation. This typically happens with conventional insemination where the egg and the sperm are placed in the same culture environment for fertilization
We use cookies to improve your experience on this website and so that ads you see online can be tailored to your online browsing interests. Ideally, between 15 - 20 mature eggs would be retrieved, though getting a number that high is uncommon. November 8 - we're having twins:) Wow!!! Cetrotide was added CD9. I'm not doing IVF, however. Clomid is cheap, easy to take (oral), drives less risk of OHSS, but is less effective. Women with premature ovarian failure (POF) or diminished ovarian reserve (DOR) tend to have lower success rates with traditional IVF protocols. It's that time of year again when gardeners all over the world are planning what to grow in their gardens. My first aIVF cycle was cx'd , due to poor/slow response and was probably due to the Birth control pills and lupron. Please re-enable javascript to access full functionality. Best of luck x Reply Quote I am about to start my 4th IVF cycle. I will probably stim for 12-13 days! 2 Girls!! Today, were seeing more well-respected doctors choosing to compliment lower dose of gonadotropin with clomid or letrozole in this group. Ovarian Stimulation Baseline Ultrasound Hey ladies, I am about to start my second IVF cycle and this time instead of priming with birth control I am doing estrogen tablets 2mg twice a day as well as a pump of androgel. TTC with DOR (Diminished Ovarian Reserve), the most helpful and trustworthy pregnancy and parenting information. I hav, My last ivf cycle was cancelled/converted to IUI due to being over suppressed by birth control pills. Has anyone with failed IVF stim tried mini/micro IVF? The protocol can also be preceded by the use of BCPs even if you have DOR. Please enable JavaScript in your browser to load the challenge. BFP oct 16th!!! You currently have javascript disabled. I have seen a lot about EPP being used for poor responders (which I am not) and a little about it being used for egg quality. So I think I was on estrogen for about a couple weeks then started stimming (antagonist protocol). It all depends on your tests and what specific information they have for you. However, for poor responders many doctors worry such a long duration of suppression can hurt outcomes. Lupron when take in larger doses suppresses pituitary function, but when taken in smaller doses, it does the opposite. Has anyone who makes a good amount of eggs used this protocol? How does a micro-flare protocol differ from mini IVF vs natural cycle? :) Keep us posted on your progress! We use data about you for a number of purposes explained in the links below. It's possible to pay with credit card or Western Union, but PayPal isn't an option. Have done 3 IUI's - 2 w. clomid and 1 with Gonal - F. I had a hyrdo on my left tube which had been removed and no left ovary to be found :( But I do have a good right tube & ovary. Yea, sometimes the smallest of tweaks can make such a big difference. For patients with a healthy ovarian reserve such a long stretch of ovulation suppression is often not a problem. Take a look at the data below published on roughly 1,000 fresh transfers and 1,000 frozen transfers. Why so many days of esterace( 15-16 days before starting/adding promethium for 10 days) then the stim cycle, 3. It is used for low/poor responders -- often women with high FSH and/or over 35 years of age. It was my best in terms of numbers and success. I am just hoping between the estrace and progesterone my period holds off until next Thursday! Beta 1117 Starting CD21, I was applying Vivelle patch every other day until my cycle started. This drug prompts the brain to release LH, the signal for ovulation, and is effective in helping to avoid OHSS. I hope you get to eat those words, I really do!!! Create an account or log in to participate. Doing mild IVF - and wondering how that is going to work as the test today was that i only had one follicle visible - Any idea what to expect? I am on my 4th now. Collection was yesterday and they retrieved 9 eggs. 6 responded, 5 retrieved, 3 fertilized normally, put all 3 back in at 3dpt - I am currently 27 weeks with one baby girl. Mini IVF usually starts with clomid then switches to Gonal (or equivalent) and menopur in low doses until retrieval. The combination of drugs and their dosing is known as a protocol and while it may seem like there are a dizzying number of protocols, the reality is there are only a few core options. IVF #2, we did estrogen priming, Follistim, Menopur, Tev Tropin (human growth hormone), Cetrotide. The deadline for sending in seeds was October 15th, but there are still plenty of ways to get involved. we did another one without BCPs and that also failed. Natural cycle is no meds to stim so u get 1 egg at best. i read everywhere it's for "poor responders". I went to a UK FSH friendly (thank you joy for the recommendation) clinic for a consultation. Lupton trigger. We have been TTC 14 months, but diagnosed at 6 months so did injectables and TI for 3 cycles without bp, although my follicles responded well. Within both, doctors can prescribe as much gonadotropin as theyd like. :) worked well for me. Hi there. That patients must use an hCG trigger they cannot use Lupron as a trigger (because theyre already taking it) which is problematic because Lupron is the only trigger shot that fends off OHSS. Find advice, support and good company (and some stuff just for fun). They studied what happens when you replace gonadotropin with clomid (a cheaper, less potent alternative) for a few days before the retrieval. Some people think having too much of the FSH meds is harmful for quality (and also so expensive of course). Thanks! It will workjust have faith! I would be doing a low stim protocol with estrogen priming. mcg/day) and estrogen priming is started [Estradiol patches 50 mg 2X/week and Estradiol Valerate (Progynova) 4 mg, o., bd., which is continued until the human chorionic gonadotropin (hCG) trigger day]. Just curious to see if any out there have had any luck getting pregnant at age 43+ and produced a child through IVF. By and large there are two easy ways to think about protocols: how much gonadotropin (the drug that prompts follicles to grow) gets used, and what other drugs get used alongside the gonadotropin which is typically what defines a given protocol strategy. I'm back from my appt and we are going with EPP. The first question is naturally, which protocol is more likely to deliver a baby, and when investigators looked at the two most popular strategies, Long Agonist and Antagonist, it became clear both were equally effective in the general IVF population. IVF Compared To Other Fertility Treatments, The Steps and Decisions In The IVF Process, Pregnancy Testing, Early Pregnancy and Delivery, The Impact of Donor Eggs, Donor Sperm or A Gestational Surrogate, The Impact of A Patients Condition or Diagnosis, Fertilization With Conventional Insemination vs. ICSI, Which Patients Benefit From Which Approach, Growing Embryos To Cleavage or Blastocyst Stage, Exceptions Where Cleavage Stage Makes Sense, PGT-A and PGS Genetic Screening of Embryos, Benefits of PGT-A (or PGS) Genetic Testing, The Negatives of PGT-A (or PGS) Genetic Screening. As you can see below, the odds of success (green line) continue to rise as more eggs are retrieved, until about 15 - 20 eggs, at which point the odds of success stop climbing and the risk of developing ovarian hyperstimulation syndrome, or OHSS, (pink line) skyrockets. Waiting for that call is sooo stressful! Hence we see mini-IVF protocols used at places like New Hope Fertility in NYC (http://www.newhopefertility.com/?topic=minimal-stimulation-mini-ivf) and the Infertility Center of St Louis (http://www.infertile.com/closlook/biograph.htm); and, Hello, Had my ER today - they got 15 eggs. There are a number of drugs that can be tacked onto the beginning of a cycle that may increase the odds of success. It's a horrifyingly traumatic experience. Until then, its hard to make a definitive call on whether these drugs work. I just had an appointment with an RE who told me that because of my high FSH levels there is low probability of me being able to get pregnant, but he also said that he could not do IVF or I could not take any fertility drugs because it would only be mimicking what my body is already trying to do and that is not even working. Twins & Multiples: Your Tentative Time Table. I'll keep my fingers crossed for you as I see you just did an IUI. I am, Hi Ladies! This amounts typically to a Coke vs. Pepsi kind of decision. . We are going to bump up my gonal f too. FertilitySmarts is a part of Janalta Interactive. After it happens, I keep receiving bills in the mail. I am planning on doing 2-3 cycles with banking and then CCS testing due to previous miscarriages. I would ask your doctor, but I guess you just do nothing while preparing for the cycle. President, ASRM This was all on the phone, so not 100 percent on what the protocol would be. It's hard for me to say definitively because I haven't had wtf yet. The combination and duration of drugs to stimulate, suppress, and incite ovulation taken together comprise a protocol. I starts on day 1 of my cycle for 25-26 days of estrace.. Not sure why.. undefined will no longer be visible to you including posts, replies, and photos. But I also realize I'm not a dr and should probably listen to their advice! We are OOP as well. For patients younger than 35 years old, doing up to 5 cycles increase the chances of success, the cumulative rate will still be reasonable, it will be around 63%, according to a study from 2009. I understand the idea for the patch is to help time the growth of follicles vs. increase the number? This is called multi-follicular development and its a pivotal step in a successful IVF. Fortunately, there are a few steps you can take to prevent and. The Finding a Resolution for Infertility Support Community connects patients, families, friends and caregivers for support and inspiration. New doctor recommended EPP to promote more even follicle growth. my RE is going back to the drawing board for my final IVF. 1997-2023 BabyCenter, LLC, a Ziff Davis company. You should also label each packet with the variety name, date, and a brief description (e.g. Several functions may not work. I stimmed for 13 days. I'm not sure what your stats are, but Check seems to have had some good success with women over 40 who have high FSH, so I'd say go with him. Was wonderin, I just finished my 3rd failed IVF cycle using EPP. High FSH. February 7 - lost our little twin, Baby B had no heartbeat at 20 weeks, June 8, 2011 - DD was born healthy and her twin brother was born to Heaven. Initial was 12. I did EPP, using a climara patch every other day starting day 8 after ovulation until period came. Went to retrieval anyway, did ICSI, but it didn't fertilize. I was not informed of this ahead of timeand was pretty upset that that they threw away something that might have had a chance. I also did ganirelix during this time. 05/18/2018 23:18 Subject : Protocol . Ivf doctor recommendation in nyc or bklyn, Low Ovarian Reserve and Poor Responder to IVF, Ladies 45 and older TTC - *infertility due to age only*. If ok, then start stimulation The many repeat bloodworks & ultrasoundsLast stimulation shot + triggerRetrievalSo I started my process in the mid-September and my retrieval happened in early NovemberAlso, I was on MicroFlare protocol, so I am not sure what other medications you might be taking. My next cycle will also be EPP. They put me on birth control pills for a month and are skipping the early stage Estrace this time around. As a result, the Antagonist strategy is generally preferred for women at especially high risk of developing OHSS, namely women with PCOS, younger women, women with high AMH or AFCs, African American women, and those who produced a high number of eggs in a recent cycle. Ultimately, for only a handful of patient types has one protocol shown itself to be superior to the others and we profile those below. There is a ton of data out there for 'younger' women 35-42 with fertility issues but I'd like to be able to g, I was taking Estrace and Androderm patch when I went in for my base sonogram and they said I was already ovulating! By clicking sign up, you agree to receive emails from FertilitySmarts and agree to our Terms of Use & Privacy Policy. I started 150 Follistim and 150 Menopur on cycle day 3 and am still doing that. I'm 35 and going through my first IVF cycle. Group Leaders communicate with staff moderators and escalate potential violations for review, but they dont moderate discussions. 10 retrieved, 6 mature, 6 fertilized (half with ICSI), transferred two 8-cell embryos on day three (both with moderate fragmentation, graded B and C-), the four remaining arrested by day 5. So I guess Im asking, do you all think I should do a EPP antogonist? EPP is an aggressive form of an IVF Antagonist Protocol. I was on the highest dosage of Gonal with that cycle. As a result, its hard to correct for confounders like the fact that harder cases may (or in our minds, probably) had been given more drug and so the underlying condition, rather than the dose taken, contributed to the lower rates of success. FertilitySmarts Inc. -
In my opinion, it's good to be at a place that uses it a lot. Fingers crossed that your period waits for the right day. Some clinics use EPP more than others. You are posting as a Guest without being logged in. Slightly higher doses of Follistim and Menopur to try to get a few more eggs. He did say there are some studies that DHEA and CoQ10 could help, but the, Hi all. View Full Term. They said they would put me in the 21 day long protocol. So there's one med w apositive side effect! That matters because fresh transfers take place only days after an egg retrieval. Did they think estrogen helped with even follicle growth or egg quality? TBD how many fertilize, etc. Just devastated with my results today so just want to cry it out and then I will respond to you. Best of luck choosing. Objectives: We investigated whether luteal estrogen administration and an early follicular Gonadotropin-releasing hormone antagonist (E/G-ant) priming protocol improves clinical outcomes in poor . I did that back in the beginning of the year but I ovulated in my own and terrified it might happen again. In my case, antral follicle count is very poor, but RE decides to proceed. Has anyone had any experience with the Estrogen Priming Protocol? This will be my first IVF round and I w, Hi All, BFN. Thanks so much! To get FSH, patients take Gonal-F or Follistim (many consider them to be interchangeable) and to get FSH-plus-LH most women take Menopur (pretty much the only product on the market). IVF#2 started sept 19th Second, this study was only done in cycles using a fresh transfer. It helps your lining and encourages your eggs to all grow at the same rate. He also said he would start with BCPs to suppress ovulation- he explained why, but at my age that just doesn't sound like a good idea to be suppressing anything. I am 40 and have a low ovarian reserve. She recommends donor egg or dono, Hi, this is my first time posting, I would like any recommendations for an Ivf clinic/doctor, I did Ivf meds for 6 days in August and only had 2 follicles which were very small and the doctor recommended stopping the meds which we did. Had two follicles but one disappeared day of egg retrieval. However, given some of the additional features for each protocol (for example, the duration of suppression), some patients might find one preferable to the others. Oh yeah that could have been it or a combo! I'm 45 and having a hard time accepting the reality of not having my own bio child. Good Morning. I did EPP with my 3rd cycle and it didn't help. During cycle 1 you use OPKs to track your LH surge and ovulation. We ended up refinancing our home and getting help from family. I am about to embark on my IVF#6 cycle (1st time at CCRM)- I've always done OCP/BCP before my IVF stim cycle(antagonist) and have produced between 15-19 eggs each time. First, make sure your seeds are dry before sending them in. Join Tomato Lovers & Participate in the Ukrainian Tribute Growout! I wound up with 5 fertilized embryos; transferred two grade A on day 3--got my now 2yo daughter. Both were immature. E2 level 96.4. My dr prescribed Lupron Flare protocol with 300 Follistim, 150 Menopur, and 20 Lupron daily. Have questions about navigating your Inspire support community or need assistance from one of our Inspire Moderators? I'm now 19 wks pregnant with #2 from embryo from same batch. - Apply first estrogen patch. Another set of investigators looked at a variation of the same question. I was at the max stim dose to get the response I did. I was 41 at SG and they also put me on BCPs and i knew it was going to oversupress me -- and it did. Changed MD's and now this is the protocol they have in place for me. HI.. hope all is well. Estrogen priming is typically done for about seven days before the start of controlled ovarian stimulation (the IVF cycle). As a result, a woman needs to start the process with many eggs. I am curious what anyone's experience has been with EPP. Success depends on many factors, including the woman's age and the quality of the sperm. This drug works indirectly by prompting the brain to produce more gonadotropin to signal the ovaries to grow follicles -- so it's not directly stimulating the ovary. (51.2% vs 25%; p = 0.047) were noted. Please whitelist our site to get all the best deals and offers from our partners. to keep trying as well as using our FSA max 3 years in a row. Below is a meta-analysis of 17 (relatively small) studies that, taken together, show the strategies have nearly identical pregnancy rates. I have been doing some research and reading and I was reading that for older patients, a different protocol where less meds are used is usually recommend. 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One med w apositive side effect say there are still plenty of ways to get all the deals...