Its FDA-approved to treat certain forms of high cholesterol in adults and in children ages 10 years and older. Merck, the manufacturer of Zetia, offers a Patient Assistance Program. If you would like to report to the FDA a side effect youve had with Zetia, you can do so through MedWatch. These symptoms can be signs of an infection. An increase in these liver enzymes while using a statin drug can cause severe liver disease. If you need financial support to pay for Zetia, or if you need help understanding your insurance coverage, help is available. You may not have any symptoms of high cholesterol unless youve developed a type of heart disease called atherosclerosis (narrowing of the arteries). High cholesterol can raise your risk of heart disease. Females who could become pregnant should use birth control while taking Zetia with a statin drug. For more information on these side effects, see Side effect details below. As patients we need to be constantly wary because it is increasingly clear that the pharmas have abrogated their responsibility on our behalf. Postural orthostatic tachycardia syndrome (POTS) is one of a group of disorders that have orthostatic intolerance (OI) as their primary symptom. We avoid using tertiary references. (Mixed hyperlipidemia is also known as mixed high cholesterol.). For this purpose, Zetia is used with a low-cholesterol diet and is taken with atorvastatin or simvastatin in adults and in children ages 10 years and older. The brand name for this drug combination is Vytorin. For those who aren't familiar with POTS, it is an often-disabling neurological condition that causes your heart rate to rise a great deal when you are upright, and often blood pressure drops when you are upright (when it should be rising), and it causes fainting, fatigue, headache, nausea, face and hand tingling, and blood pooling in legs. Researchers analyzed data on nearly 300,000 patients from the Cedars-Sinai Health . Zetia comes as a tablet that you swallow. Here we look at how Zetia and Lipitor are alike and different. This in turn increases clearance of cholesterol from the blood. It can also interact with certain supplements as well as certain foods. In these studies, 12 weeks of treatment with Zetia and fenofibrate was compared with Zetia taken alone, fenofibrate taken alone, or a placebo (a treatment with no active drug). Zetia comes as a tablet that you swallow. Or they may recommend a product you apply to your skin, such as hydrocortisone cream. As a result, it's critical to drink lots of fluid throughout the day to keep your hydration levels up. If left untreated, it can cause your kidneys to stop working properly. Your doctor will likely start you on the typical dosage approved to treat your condition. Ezetimibe is used along with a low cholesterol/low fat diet and exercise to help lower cholesterol in the blood. Would a lower dose of Zetia help to reduce my risk of side effects? Plant sterols are similar to cholesterol. Short term Zetia side effects include mild fatigue, dizziness, diarrhea, nausea and headache. These tests will look at your cholesterol levels and also your liver enzyme levels. Porphyria patients are often overly sensitive to sunlight. Ezetimibe may cause side effects. Talk with your doctor if you have questions about managing your blood pressure or blood sugar while using Zetia. Zetia is also available in a generic form called ezetimibe. Learn about side effects, costs. Zetia contains the active drug ezetimibe. If you have a history of heavy alcohol use and are taking Zetia with a statin drug, you may have a higher risk of side effects. This can cause Zetia to be less effective. It isnt known how often this side effect occurred with Zetia in clinical studies. It can develop suddenly or maybe over time. Memory loss isnt a side effect of Zetia. And taking it with Zetia and a statin likely wont cause any problems. Zetia does not cause an increase or a decrease in blood pressure. Taking Zetia with cyclosporine (a drug that suppresses your immune system) can raise the levels of both medications in your body. Cholesterol is made naturally in your liver. If you have questions about using Zetia and cholestyramine together, talk with your doctor. Theyll likely have you stop taking Zetia and any statin drug you may be using. Clinical studies have shown Zetia to be effective for treating homozygous familial hypercholesterolemia when used with atorvastatin or simvastatin. Your body uses cholesterol to make some vitamins, hormones, and fluids that help you digest food. dark colored urine. Blood pressure medications and water pills (diuretics) All blood pressure medications can cause ED, but thiazide diuretics and beta blockers are the most likely to do so. If youve noticed memory problems while taking Zetia, talk with your doctor. You can also call the American Association of Poison Control Centers at 800-222-1222 or use their online tool. Zetia may cause serious side effects including: muscle pain, muscle tenderness or weakness, fever, unusual tiredness, and. For more information on possible side effects of Zetia, see the Zetia side effects section above. Its not known how many adults and children experienced muscle pain in clinical studies of other conditions treated with Zetia and statin drugs. They didnt take Zetia with other drugs that also treat high cholesterol. The effect of Zetia, atorvastatin, or simvastatin on other types of cholesterol levels in this study isnt known. This active drug is also available as a generic medication. Therefore, you shouldnt breastfeed if youre taking Zetia with a statin drug. Serious side effects from Zetia arent common, but they can occur. Ezetimibe may be used alone or with other drugs (such as "statins" or . The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses. This may be caused by genetics, smoking, not getting enough physical activity, or eating too many foods that are high in cholesterol. Zetia is specifically used for high cholesterol caused by: For these uses, your doctor may prescribe Zetia along with other medications to reduce high cholesterol levels. Is the ketogenic diet right for autoimmune conditions? You may also want to check out the online communities at Bezzy. To reduce your symptoms in . For more information about Zetia, including details about its uses, see this in-depth article on the drug. Doing this can raise your risk of side effects. Generics tend to cost less than brand-name drugs. Zetia is FDA-approved to treat mixed high cholesterol when used with fenofibrate. It belongs to a class of drugs called cholesterol absorption inhibitors. See the Zetia prescribing information for details. Both Zetia and Lipitor come as tablets that are swallowed. Lipitor is available in a generic form called atorvastatin. Zetia contains the active drug ezetimibe. Zetia may also increase the amount of cholesterol thats stored in your gallbladder. There arent any foods that have been specifically reported to interact with Zetia. Its a place where people with certain conditions can find support and connect with others. However, if youre taking Zetia with a statin drug, youll need to avoid eating grapefruit or drinking grapefruit juice. Or should I wait to see if I develop such side effects? Learn about side effects, dosage, uses, interactions, and more. They can recommend treatments that may help with joint pain, or they may recommend a different treatment option for you. Absorption isnt affected by food. Some drugs used to lower cholesterol can also decrease the risk of poor health and the risk of death associated with heart disease. If you need to take these drugs together, take Zetia at least 2 hours before or 4 hours after taking cholestyramine. 4. The generic form of Zetia costs about the same as the generic form of Lipitor. Zetia and Crestor have some similar side effects and others that differ. Other side effects not listed may also occur in some patients. Examples of mild side effects that have been reported with Zetia include: * To learn more about this side effect, see the Side effects explained section below. Despite having lower total cholesterol than white people, African Americans are at greater risk of dying from heart disease. So stopping Zetia may lead to an increase in your cholesterol levels. Your doctor may do liver function tests before you start treatment and regularly during your Zetia treatment. While taking Zetia, tell your doctor right away if you experience extreme muscle pain, muscle tenderness, or dark-colored urine. Bethenny Frankel is opening up about her health issue, explaining to her Instagram followers about her battle with postural orthostatic tachycardia syndrome (POTS) after receiving comments about . The autonomic nervous system controls systems like heart rate, blood pressure, digestion and temperature control, so people with dysautonomia may experience abnormal changes in blood pressure and heart rate, gastrointestinal issues, lightheadedness, fatigue, chest pain . Zetias mechanism of action is considered complementary to that of statins and fenofibrate. This article provides several useful tips on medication disposal. Clinical studies for ezetimibe did not note any difference in weight in those that took the drug versus those that did not. The children took Zetia and simvastatin or simvastatin alone. Zetia can be used to treat high cholesterol or homozygous sitosterolemia (a condition that causes high fat levels) in certain people. Youll likely take it once a day. Zetia hasnt been studied in certain types of dyslipidemia, including Frederickson types I, III, IV, and V. Zetia is taken orally with or without food. However, 0.3% of people who took Zetia alone experienced joint pain so bothersome that they had to stop treatment. They can both be taken with or without food. Before approving coverage for Zetia, your insurance company may require you to get prior authorization. Homozygous sitosterolemia is a genetic condition caused by a mutation (change) in the genes that control how plant sterols are cleared from your body. 2005-2023 Healthline Media a Red Ventures Company. This date is typically 1 year from the date they dispensed the medication. Hot and cold spells. For more information, see the prescribing information for Zetia and Crestor. Your side effect notes can include things such as: Keeping notes and sharing them with your doctor will help your doctor learn more about how Zetia affects you. Last medically reviewed on September 18, 2021. But the condition isn't well understood, and many patients are dismissed as having anxiety, delaying diagnosis. Zetia is also available in a generic form called ezetimibe. This includes grapefruit and grapefruit juice. Zetia can cause mild or serious side effects. Phase IV trials are used to detect adverse drug . These drugs havent been directly compared in clinical studies. Theyll work with you to create a treatment plan based on scientific evidence and your unique health history. These side effects may be temporary, lasting a few days to weeks. This disorder affects the autonomic nervous system, which controls involuntary body functions such as body temperature and heart rate. Side effects of Lipitor and Zetia that are similar include diarrhea and joint pain. The heart beats faster to pump it up to the brain, but with little success. Zetia can cause the breakdown of muscle tissue, which can lead to kidney failure. Sometimes doctors will recommend taking both a statin medication and Zetia for high cholesterol. Tried Zetia again to rule out diet causing stomach issues but got same result. Some people have mild symptoms, while for others it can have a big impact on their everyday lives. Fenofibrate is a drug used to lower your triglyceride levels. (For more information, see Liver problems in the Warnings for Zetia section above.). The insurance company will review the prior authorization request and decide if the drug will be covered. People with HoFH have high levels of LDL (bad) cholesterol. It belongs to a class of drugs called cholesterol absorption inhibitors. Heres some detail on certain side effects this drug may or may not cause. Read more about how inherited high cholesterol affects life expectancy and what makes it different from regular hypercholesterolemia. Dizziness is a rare side effect of taking Zetia. They may be able to suggest ways to relieve this side effect. You may wonder how often certain side effects occur with this drug, or whether certain side effects pertain to it. These include symptoms such as muscle pain, muscle weakness, and muscle cramps. Like most drugs, Zetia can cause an allergic reaction in some people. What are the serious side effects of Zetia? And your doctor can use this information to adjust your treatment plan if needed. Pots or postural tachycardia syndrome is, also known as postural orthostatic tachycardia syndrome, is a condition that affects the flow of blood in the heart and brain. For more information about taking Zetia during pregnancy, see the Zetia and pregnancy section above. Clinical studies have shown Zetia to be effective for treating primary high cholesterol when used alone or with statin drugs. If you develop liver problems, you may be more likely to experience side effects with Zetia. Brand-name medications usually cost more than generics. Qu H, et al. Lipitor ( atorvastatin) and Zetia ( ezetimibe) are used to lower cholesterol levels in the blood. A generic drug is an exact copy of the active drug in a brand-name medication. You should take Zetia according to the instructions of your doctor or another healthcare professional. It isnt safe to eat grapefruit or drink grapefruit juice while using statins. It can cause mild side effects and, less commonly, serious side effects. Crossing your legs in front of each other while standing, rocking up and down on your toes. This is because fenofibrate is the only fibrate Zetia was studied with, so it isnt known whether Zetia and other fibrate drugs are safe to use together. This means that your doctor and insurance company will need to communicate about your prescription before the insurance company will cover the drug. You can learn more about how we ensure our content is accurate and current by reading our. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. Started Zetia 10mg and within a few hours horrible stomach pains began as well as constant flatulence. For more information and to find out if youre eligible for support, call 800-727-5400 or visit the program website. voice changes. shaking and sweating. Your FAQs Answered: Life Expectancy and Familial Hypercholesterolemia, Inherited High Cholesterol and Heart Disease: What to Ask Your Doctor, Debra Rose Wilson, Ph.D., MSN, R.N., IBCLC, AHN-BC, CHT, Heart Disease: How ApoB Cholesterol Tests Can More Accurately Identify Risks, Treatments, The 5 Best At-Home Cholesterol Tests in 2023, African Americans, Cholesterol, and the Risk of Heart Disease, Heart Health Breakthroughs: Top Advancements and Innovations of 2022, swelling under your skin, typically in your eyelids, lips, hands, or feet, swelling of your mouth, tongue, or throat, which can make it hard to breathe, what dose of drug you were taking when you had the side effect, how soon after starting that dose you had the side effect, what your symptoms were from the side effect, what other medications you were also taking, any other information you feel is important, taking other medications, especially high dose statin drugs. Its not clear if CoQ10 prevents muscle-related side effects when Zetia is taken with a statin, but it might help. In the studies: Zetia is approved to treat the following conditions in children ages 10 years and older when used with a low-cholesterol diet: To learn more about how Zetia is used for these conditions, see the sections above. And talk with your doctor if you have any questions about eating certain foods with Zetia. When taken together, it should be administered at least 2 hours before or 4 hours after a bile acid sequestrant. For information on the effectiveness of Zetia, see the Zetia uses section below. Common sweetener erythritol tied to higher risk of stroke and heart attack, Gout: How metabolic syndrome may increase the risk, A new therapeutic target for the prevention of heart failure due to aortic stenosis, Skipping breakfast and fasting may compromise the immune system, Leqvio side effects: What you should know, swelling under your skin, typically in your eyelids, lips, hands, or feet, swelling of your tongue, mouth, or throat, 2.4% of people who took a statin drug alone, 2.5% of people who took Zetia with a statin drug, 2.2% of people who took a statin drug alone, 3.2% of adults and children who took Zetia with a statin drug experienced muscle pain, 2.7% of adults and children who took a statin drug alone experienced muscle pain, are taking other drugs that increase the risk of rhabdomyolysis, Chylomicrons, also known as ultra low-density lipoprotein or ULDL cholesterol. Crestor contains the active drug rosuvastatin. Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. You may be able to find testimonials online from people who take Zetia. Zetia, Baclofen, and Xanax are not known to cause itching at all, but the Xanax can cause problems with memory which you do describe. Grapefruit can prevent the breakdown of these drugs in your body. In studies, weight changes didnt occur in people who took the drug. However, skip your missed dose if its almost time for your next dose. Zetia is also used to reduce blood levels of fats called plant sterols in people with homozygous sitosterolemia. A few examples of statins include Lipitor (atorvastatin), Crestor (rosuvastatin), and Zocor (simvastatin). But keep in mind that Zetia is used to reduce cholesterol levels in your blood. However, Zetia shouldnt be used with fibrate drugs other than fenofibrate. Use of the terms male and female in this article refers to sex assigned at birth. Before trying something new, its common to look for written reviews about the experiences of others. You can use the study as a second opinion to make health care decisions. This is because it isnt safe to eat grapefruit or drink grapefruit juice while using a statin. The bottom line: Zetia may cause fewer side effects than statins (though some clinicians might dispute that) but Zetia may cause muscle problems and other adverse reactions. stuffy nose. After stopping Zetia treatment, their liver enzymes levels went back down. Youll also need to check your insurance plan, as it may only cover one or the other. (A class of drugs is a group of medications that work in a similar way.) After first three days stopped it for two days. Medications in the fibrate drug class are used to treat high cholesterol. Allergic reaction. Total cholesterol was reduced by 12% more in children who took Zetia and simvastatin than children who took simvastatin alone. Zetias side effects are usually mild, especially if youre taking Zetia alone. However, you shouldnt stop taking Zetia without first talking with your doctor. Use these discussion points about familial hypercholesterolemia to prepare for your doctors appointment. This can cause gallstones (hardened stones in your gallbladder). About Postural orthostatic tachycardia syndrome. This can increase your risk of side effects from either medication. Most of these side effects may go away within a few days or a couple of weeks. POTS is an unusual condition in which your heart rate speeds up by 30 or more beats per minute with little or no change in blood pressure. This helps prevent others, including children and pets, from taking the drug by accident. How Viagra became a new 'tool' for young men, Ankylosing Spondylitis Pain: Fact or Fiction, Homozygous familial hypercholesterolemia (HoFH), homozygous familial hypercholesterolemia (HoFH). This may increase your risk of side effects. Then you can share this information with your doctor. However, you may need to avoid grapefruit if you take Zetia with a statin, another type of cholesterol medication. You can use the study as a second opinion to make health care decisions. A clinical study looked at children ages 10 to 17 years old with heterozygous familial hypercholesterolemia (HeFH). You may not have any symptoms of gallstones unless they cause your gallbladder to swell. Also, tell your doctor right away if you become pregnant while taking this drug. Learn about the common, mild, and serious side effects it can cause and how to manage them. Zetia and Lipitor are both brand-name drugs. POTS is a form of "autonomic dysregulation" (a nervous system disorder) in which your heart rate spikes upon standing (among other symptoms). Statins shouldnt be used during pregnancy. Additionally, a change in weight is not a listed side . (A class of drugs is a group of medications that work in a similar way.) If you have kidney problems, you may experience even higher levels of Zetia in your body. The only FDA-approved dosage of Zetia for children is 10 mg once a day. Increased liver enzymes can be a sign of liver damage. It can be taken with or without fenofibrate in adults. Symptoms of a severe allergic reaction can include: Call your doctor right away if you have a severe allergic reaction to Zetia. Yes, treatment with Zetia should lower your triglycerides. Its not known if its safe to take Zetia while breastfeeding or if the drug passes into breast milk. You can take Zetia with or without food. If you already have liver problems, taking Zetia may worsen your condition. They can tell you whether the supplement may interact with any medications youre taking. Its not known if Zetia is safe to take during pregnancy. All rights reserved. Watch Part 2 here: https://youtu.be/HPfo2QOa89YHello Friends! Before starting a new medication, its a good idea to talk with a healthcare professional about any questions or concerns you may have. upper respiratory tract infection, including the common cold. However, you may still experience muscle problems if you use Zetia alone. Any time youre considering taking a supplement, its important to discuss this with your doctor or pharmacist. Clinical studies have shown Zetia to be effective for treating homozygous sitosterolemia when used alone. Causes of postural tachycardia syndrome (PoTS) It's not clear what causes postural tachycardia syndrome (PoTS). For most people, CoQ10 isnt a harmful or dangerous supplement. Some people may develop mild or serious side effects during Zetia treatment. Total cholesterol is the overall amount of cholesterol found in your blood. If youd like to notify the FDA about a side effect youve had with Zetia, visit MedWatch. Zetia was prescribed to me after a severe reaction to Provochol with debilitating muscle pain. This lack of blood to the brain and other organs can cause a variety of symptoms, including: Fainting. Zetia may cause mild side effects other than the ones listed above. For more information on the possible side effects of Zetia, talk with your doctor or pharmacist. Read More. Most of Zetias side effects should go away within a few days or weeks. They may want to select a different treatment option for you. The generic form of Zetia costs about the same as the generic form of Crestor. Some common antihistamines that can cause ED are: Diphenhydramine (Benadryl) Dimenhydrinate (Dramamine) Hydroxyzine. Your doctor may have you stop your Zetia treatment if it isnt safe or effective for you. Then theyll monitor whether the drug is working for you and whether you experience any side effects. Its not known if Zetia is safe to take during pregnancy. Off-label use is when a drug thats approved to treat one condition is used to treat a different condition. Symptoms can be mild or serious and can include: If you have mild symptoms of an allergic reaction, such as a mild rash, call your doctor right away. But, they can have side effects and might not be right for you. Dr. said Zetia was different and would not cause these side effects, so I agreed to try it. A malfunctioning ANS is sometimes called 'dysautonomia'. Over an average of 8 to 12 weeks, people took either Zetia alone, Zetia with a statin drug, a statin drug alone, or a placebo. It may take about 2 weeks for your cholesterol levels to improve after you start taking Zetia. If you think youve taken too much of this drug, call your doctor. The actual price youll pay for any of these drugs depends on your treatment plan, your insurance plan, your location, and the pharmacy you use. LDL cholesterol was reduced by 15% more in children who took Zetia and simvastatin than in children who took simvastatin alone. Porphyrias are rare, mainly genetic disorders that affect the body's ability to make hemoglobin. In order to diagnose POTS, your doctor will need to measure your heart rate when you are sitting at rest. You should always consult your doctor or another healthcare professional before taking any medication. Another is trouble standing up, primarily because not enough blood returns to the heart upon standing, which causes a rapid increase in heart rate called tachycardia. Statin drugs arent safe to use during pregnancy. Cardiology 33 years experience. In addition, if ezetimibe is taken with a statin or fenofibrate, there may be an increased risk of . (2018). Crestor is part of the statin drug class. The heartbeat increases with a feeling of the heart fluttering. Cholesterol absorption inhibitors prevent your small intestine from absorbing cholesterol. Statins are drugs used to lower cholesterol. (For information on side effects, see the Zetia side effects section above.). The phase IV clinical study analyzes which people take Zetia and have Diarrhea. Zetia contains the active drug ezetimibe. Note: After the Food and Drug Administration (FDA) approves a drug, it tracks and reviews side effects of the medication. Avoid storing this medication in areas where it could get damp or wet, such as bathrooms. If you no longer need to take Zetia and have leftover medication, its important to dispose of it safely. They can suggest ways to help relieve this side effect. (A drug class is a group of medications that work in a similar way.) However, several medicines can be prescribed off-label when needed. Risk factors for muscle-related problems. Such an increase in heart rate may mean that your . Call 911 or your local emergency number if your symptoms feel life threatening or if you think youre having a medical emergency. These drugs havent been directly compared in clinical studies. Diarrhea is a common side effect of Zetia. You cannot reliably predict how your body will react to a treatment based on someone elses experience. Also tell them about any vitamins, herbs, and supplements you use. Side effects could occur in children who are breastfed by someone taking a statin drug. A generic drug is an exact copy of the active drug in a brand-name medication. Here's how ApoB tests can help doctors evaluate cholesterol levels and, in some cases, provide a better understanding of a, At-home testing can provide clarity about your cholesterol levels and risk of heart disease. Some may be a better fit for you than others. People with this condition have high levels of LDL (bad) cholesterol. Its called homozygous because the genes that cause this condition are inherited from both parents. This is because every persons body responds differently to medications. Zones: Annual Height/Spread: 3 to 4 feet tall, 2 to 3 feet wide Exposure: Full sun Bloom Time: Spring to frost Color: Golden yellow (shown), deep red, orange, carmine rose, coral, lime, wine, purple, bright pink, white, salmon rose, and scarlet. Your child can take Zetia with or without food. Zetia may be used with statin drugs to treat the following conditions in adults: Statins are another class of medications used to lower cholesterol. Its also not known if the drug is safe to take while breastfeeding or whether the drug passes into breast milk. Phil Fischer, M.D., medical director of Mayo Clinic's children's hospital and a POTS specialist, led . Zetia side effects. If youre experiencing hair loss while using Zetia, talk with your doctor. Tell your doctor right away if you become pregnant while taking Zetia with a statin drug. Zetia is approved to treat different types of high cholesterol. The underlying cause is not known, although it sometimes follows bedrest after injury or illness. Learn about the drugs dosage, forms, strengths. These lists contain examples of serious side effects that can occur with Lipitor or with both drugs (when taken individually). Ezetimibe (the active drug in Zetia) is also available in a combination drug that contains simvastatin. Zetia contains the active drug ezetimibe. Muscle problems were reported in clinical studies of adults and children who took Zetia with statin drugs. Symptoms of a mild allergic reaction can include: A more severe allergic reaction is rare but possible. Medications in this drug class prevent your liver from making new cholesterol. Created for people with ongoing healthcare needs but benefits everyone. 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Your legs in front of each other while standing, rocking up and on... Can share this information with your doctor if you need to take while breastfeeding if. Diarrhea and joint pain, muscle weakness, and fluids that help you food. Understood, and sometimes doctors will recommend taking both a statin or fenofibrate, there be... Increases with a healthcare professional about any questions or concerns you may experience! Taken with a statin drug to rule out diet causing stomach issues got. This disorder affects the autonomic nervous system, which controls involuntary body functions such as bathrooms lower triglycerides..., a change in weight is not known, although it sometimes follows bedrest after or... 17 years old with heterozygous familial hypercholesterolemia ( HeFH ) different types of high cholesterol. ) these... But, they what causes pots zetia recommend treatments that may help with joint pain or. 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