1990 Feb;24(2):162-6. In most cases, adult patients require a cumulative dose of elemental iron of at least 1 g. Most commonly, iron replenishment therapy is done intravenously: As total dose (iron-dextran or iron carboxymaltose); Iron deficiency is common during childhood growth, prolonged periods of sickness, in convalescence or during pregnancy. Objective. Applies only to oral form of both agents. This may be helped by giving the medication more slowly or at a lower dose. -Hgb deficit (grams) = Hgb deficit (g/dL) x blood volume (dL) -Iron deficit (mg) = Hgb deficit (grams) x 3.3 (mg Fe/g Hgb) [Note: 3.3 x 0.65 = 2.145] -Volume of parenteral iron product req'd (mL) = [Iron deficit (mg)] / C(mg/mL) Final calculations: -Hgb iron deficit (mg) = weight (kg) x (14 - Hgb) x (2.145) -Volume of product required (mL) = [weight (kg)x (14 - Hgb) x (2.145)] / C Where C= concentration of elemental iron (mg/ml) in the product being used: Iron dextran: 50 mg/mL. In post-marketing safety studies of Venofer in 1,051 patients with HDD-CKD, adverse reactions reported by >1% were cardiac failure congestive, sepsis and dysgeusia. May increase risk of hypotension. Fatal reactions have followed the test dose of iron dextran injection. Normal haemoglobin values are gender specific: for males from 13.8 to 18.0 g/dL (138 to 180 g/L, or 8.56 to 11.17mmol/L) and females from 12.1 to 15.1 g/dL (121 to 151 g/L, or 7.51 to 9.37mmol/L). Only administer Feraheme as an intravenous infusion over at least 15 minutes and only when personnel and therapies are immediately available for the treatment of anaphylaxis and other hypersensitivity reactions. Hypotension following administration of Venofer may be related to rate of administration and/or total dose delivered. Use Caution/Monitor. Use Caution/Monitor. Venofer Injection Dosage Guide - Drugs.com MDCalc loves calculator creators researchers who, through intelligent and often complex methods, discover tools that describe scientific facts that can then be applied in practice. Iron Sucrose (Ferogen): Indications, Dosage, Administration - Medcrine The dosing of Monofer was performed according to the Simplified Table as described in section 4.2 above and dosing of iron sucrose was calculated according to Ganzoni and administered as 200 mg infusions. Do not administer Venofer to patients with evidence of iron overload. Use Caution/Monitor. pantoprazole will decrease the level or effect of iron sucrose by increasing gastric pH. To provide clinicians with evidence-based guidance for iron therapy dosing in patients with iron deficiency anemia (IDA), we conducted a study examining the benefits of a higher cumulative dose of intravenous (IV) iron than what is typically administered. Kumpf VJ, Holland EG. Parenteral iron dextran therapy. rabeprazole will decrease the level or effect of iron sucrose by increasing gastric pH. iron sucrose, captopril. Do not mix iron sucrose with other medications or TPN solution. cimetidine will decrease the level or effect of iron sucrose by increasing gastric pH. Applies only to oral form of both agents. Minor/Significance Unknown. The weight of the patient is taken into account in order to estimate iron stores, while haemoglobin is required as both current measured and target. iron sucrose increases levels of calcium chloride by enhancing GI absorption. Interaction only with oral iron administration. calcium citrate decreases levels of iron sucrose by inhibition of GI absorption. For iron maintenance treatment: Administer Venofer at a dose of 0.5 mg/kg, not to exceed 100 mg per dose, every two weeks for 12 weeks given undiluted by slow intravenous injection over 5 minutes or diluted in 0.9% NaCl at a concentration of 1 to 2 mg/mL and administered over 5 to 60 minutes. 3) Bayraktar UD, Bayraktar S. (2010) Treatment of iron deficiency anemia associated with gastrointestinal tract diseases. Venofer may reduce the absorption of concomitantly administered oral iron preparations. Minor/Significance Unknown. Iron sucrose: 20 mg/mL. Minor/Significance Unknown. PDF GUIDELINES FOR IRON INFUSION USE IN ADULTS - Brockville General Hospital Your body may also need more iron if you use the drug erythropoietin to help make new red blood cells.Iron is an important part of your red blood cells and is needed to transport oxygen in the body. Coadministration of ciprofloxacin with multivalent cation-containing products may reduce the bioavailability of ciprofloxacin by 90%. Applies only to oral form of both agents. Applies only to oral form of both agents. Either increases effects of the other by pharmacodynamic synergism. The dosage of Venofer is expressed in mg of elemental iron. Most If you log out, you will be required to enter your username and password the next time you visit. Nutrition. Applies only to oral form of both agents. For males: LBW = 50 kg + 2.3 kg for each inch of patients height over 5 feet For females: LBW = 45.5 kg + 2.3 kg for each inch of patients height over 5 feet Administration: I. Dosing for patients who weigh 50 kg or more For patients weighing 50 kg (110 lb) or more: Give Injectafer in two doses separated by at least 7 days. Human studies not conducted. Applies only to oral form of both agents. Multivalent cation-containing products may impair absorption of tetracyclines, which may decrease its efficacy. Anemia of chronic disease (ACD), Calculation of the Total Iron Deficit equation appears in Cosmofer PI, Iron Dextran Dosing Calculator (iron deficit). Oral and parenteral products - see background option for oral products. Minor/Significance Unknown. Symptoms associated with Venofer total dosage or infusing too rapidly included hypotension, dyspnea, headache, vomiting, nausea, dizziness, joint aches, paresthesia, abdominal and muscle pain, edema and cardiovascular collapse. It varies from increases in dietary intake of iron (usually for prophylaxis purposes) to oral, intramuscular or intravenous therapy. Applies only to oral form of both agents. The initial hemoglobin rise is more rapid with parenteral iron but on the long term (12 weeks), both therapies reach similar levels of hemoglobin. Most studies have used IV iron sucrose (maximum dose of 200 mg per setting) or ferric carboxymaltose (maximum dose of 1000 mg per week). Injection: 50 mg/2.5 mL, 100 mg/5 mL, or 200 mg/10 mL (20 mg/mL) in single-dose vials. Monitor Closely (1)iron sucrose decreases levels of ibandronate by inhibition of GI absorption. Test Dose: Not required. Iron Deficiency Calculator Perinatology and Obstetrical Calculators Applies only to oral form of both agents. Studies in monkeys showed concurrent use with calcium, aluminum, or iron caused significantly decreased plasma levels. gymnema decreases levels of iron sucrose by inhibition of GI absorption. Serious - Use Alternative (1)iron sucrose decreases levels of demeclocycline by inhibition of GI absorption. 1974 Jun;31(6):592-5. Applies only to oral form of both agents. Use Caution/Monitor. Symptoms of a serious allergic reaction may include: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.This is not a complete list of possible side effects. Last updated 28/06/2018 Enter values here and press 'Calculate'. Steps on how to print your input & results: 1. Each mL contains 20 mg of elemental iron. It is usually given slowly over 2 to 5 minutes or as directed by your doctor. Venofer (iron sucrose injection, USP) is a brown, sterile, aqueous, complex of polynuclear iron (III)- . Monitor Closely (1)iron sucrose will decrease the level or effect of sarecycline by inhibition of GI absorption. Copyright 2014 - 2023 The Calculator .CO |All Rights Reserved|Terms and Conditions of Use, Parenteral Iron Replacement For Iron Deficiency Anemia Calculator, Intravenous Iron Therapy in Patients with Iron Deficiency Anemia: Dosing Considerations, Clinical use of the total dose intravenous infusion of iron dextran, When is high-dose intravenous iron repletion needed? Serious hypersensitivity reactions, including anaphylactic-type reactions, some of which have been life-threatening and fatal, have been reported in patients receiving Venofer. Copyright 2021 GlobalRPH - Web Development by. Total cumulative Venofer dose = number of 100mg ampoules for Hb increase. Monitor Closely (1)iron sucrose decreases levels of methyldopa by inhibition of GI absorption. Minor/Significance Unknown.iron sucrose increases levels of calcium chloride by enhancing GI absorption. Only administer Venofer when personnel and therapies are immediately available for the treatment of serious hypersensitivity reactions. Drug Des Devel Ther; 5: 5160. Parenteral iron dextran therapy: a review. By using this form you agree with the storage and handling of your data by this website. The Ganzoni equation used by the iron deficiency calculator is the following: Total iron deficit (mg) = Weight in kg x (Target Hb - Actual Hb in g/dL) x 2.4 + Iron stores The recommendation is that most adults need a cumulative dose of elemental iron of at least 1 g. Shirley, NY: American Regent, Inc.; 9/2020. ------------------------------------------------------------------------- Ferric Carboxymaltose [ Injectafer ] Elemental iron: Injectafer contains 50 mg of elemental iron - 750 mg/15 mL [package insert] Indications: Injectafer is indicated for the treatment of iron deficiency anemia in adult patients: who have intolerance to oral iron or have had unsatisfactory response to oral iron; who have non-dialysis dependent chronic kidney disease. Administer iron products at least 2 hr before and no less than 6 hr after each dose to avoid chelation with magnesium. Recommended dosage for patients weighing less than 50kg (110lb): Give Injectafer in Indications: Ferrlecit is an iron replacement product for treatment of iron deficiency anemia in adult patients and in pediatric patients age 6 years and older with chronic kidney disease receiving hemodialysis who are receiving supplemental epoetin therapy. 2 Protocol for Intravenous iron sucrose - Venofer 2.1 Dosage The total cumulative dose of Venofer should be calculated using the table below. iron sucrose decreases levels of levofloxacin by inhibition of GI absorption. You may report side effects to Health Canada at 1-866-234-2345. . The original formula employs the weight in kg but users can input it in lbs and it gets transformed. Prior to and at regular intervals during parenteral iron therapy, evaluate serum iron, hemoglobin, and hematocrit. 1996 Aug;11(4):139-46. Baloxavir may bind to polyvalent cations resulting in decreased absorption. PDF Venofer Guidelines for Use 2011 - University Health System Modify Therapy/Monitor Closely. Applies only to oral form of both agents. Medscape Education, Improving Quality of Care in Patients With Iron Deficiency Anemia and Inflammatory Bowel Disease, 2010feosol-carbonyl-fe-icar-c-carbonyl-iron-342171Drugs, encoded search term (iron sucrose (Venofer)) and iron sucrose (Venofer), Use of High-Dose Iron in Dialysis in US Tracks PIVOTAL Trial, FDA Watch List Adds Drugs With Anaphylaxis, Herpes, Fetal Death Risk, Dialysis Industry Mergers: Profits Rise as Patient Outcomes Worsen, Hematology-Oncology Guidelines: 2017 Midyear Review. Multiple placebo-controlled, randomized clinical trials have been conducted with IV iron in patients with New York Heart Association class II-III heart failure with an ejection fraction 45% who met criteria . Either increases effects of the other by pharmacodynamic synergism. You can further save the PDF or print it. Venofer Dosing and Administration Avoid or Use Alternate Drug. Calculation of Dosage of Nefrofer Total Iron Deficit (mg) Nefrofer (ml) = 20mg/ml Total Iron Deficit (mg) = Body weight (kg) x (Target Hb - Actual Hb) [g/l] x 0.24* + Depot Iron . Comparable efficacy to that of IV iron sucrose. The dosage of Venofer is expressed in mg of elemental iron. (3) Known hypersensitivity to Venofer. Written by ASHP. Use Caution/Monitor. Use (s): Iron deficiency anemia in patients with chronic kidney disease (CKD) Otherwise, call a poison control center right away. Minor/Significance Unknown. Applies only to oral form of both agents. Iron stores are input as default 500 mg on the assumption that the patient weight is greater or equal to 35 kg (77 lbs). The dosage of Venofer is expressed in mg of elemental iron. Monitor Closely (1)esomeprazole will decrease the level or effect of iron sucrose by increasing gastric pH. The dosing for iron replacement treatment in pediatric patients with HDD-CKD has not been established. Applies only to oral form of both agents. Sodium ferric gluconate (Ferrlecit) 62.5 mg . A maximum dose of 1000 mg iron can be delivered intravenously over 15 minutes, which may make it a suitable treatment for iron-deficiency anaemia outside of the hospital setting. Recommended Treatment Regimen Using IV Iron Sucrose for Initial Repletion in Children With Iron Deficiency Anemia. Individual plans may vary Parenteral Iron Replacement For Iron Deficiency Anemia Calculator iron sucrose decreases levels of tetracycline by inhibition of GI absorption. . Applies only to oral form of both agents. The prevention and treatment of iron deficiency is a major public health goal, especially in women, children, and individuals in low-income countries. ------------------------------------------------------------------------- Iron Dextran Complex [ Infed ] Elemental iron: 50 mg of elemental iron per mL [2 mL] [package insert] BOXED WARNING: WARNING: RISK FOR ANAPHYLACTIC-TYPE REACTIONS Anaphylactic-type reactions, including fatalities, have followed the parenteral administration of iron dextran injection. We first individually analyzed 5 clinical studies, averaging the total iron deficit across all patients utilizing a . Use Caution/Monitor. Applies only to oral form of both agents. Monitor Closely (1)ibuprofen/famotidine will decrease the level or effect of iron sucrose by increasing gastric pH. Symptoms associated with Venofer total dosage or infusing too rapidly included hypotension, dyspnea, headache, vomiting, nausea, dizziness, joint aches, paresthesia, abdominal and muscle pain, edema and cardiovascular collapse. Applies only to oral form of both agents. Separate dosing of tetracyclines from these products. The cost of Venofer is $145 for a dose of 300 mg and Monoferric is $274 for a dose of 500mg. Ferrlecit may be diluted in 100 mL of 0.9% sodium chloride administered by intravenous infusion over 1 hour per dialysis session. This parenteral iron replacement for iron deficiency anemia calculator determines the parenteral dose of iron supplement needed to replenish iron stores and hemoglobin levels. Alldredge BK, Corelli RL, Ernst ME, Guglielmo BJ, eds. Avoid or Use Alternate Drug. Case G. Maintaining iron balance with total-dose infusion of intravenous iron dextran. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Multivalent cation-containing products may impair absorption of tetracyclines, which may decrease its efficacy. Replacement of iron stores found in hemoglobin, myoglobin, and enzymes; works to transport oxygen via hemoglobin, Do not mix with other medications or add to parenteral nutrition solutions for IV infusion, Do not dilute to concentrations below 1 mg/mL, Add dose to 0.9% NaCl infusion bags (PVC or non-PVC); final concentrations range is 1-2 mg of elemental iron/mL, Visually inspect for particulate matter and discoloration prior to infusion, Stable for 7 days at controlled room temperature (25C). Intravenous iron-dextran: therapeutic and experimental possibilities, Intravenous Iron Therapy in Patients with Iron Deficiency Anemia: Dosing Considerations, Diagnosis and management of iron deficiency anaemia: a clinical update. FOR PATIENTS WEIGHING LESS THAN 50 kg: Administer Monoferric as 20 mg/kg actual body weight by intravenous infusion 20 minutes . Most 4. LBW = Lean body weight in kg. Minor/Significance Unknown.iron sucrose increases levels of calcium carbonate by enhancing GI absorption. Applies only to oral form of both agents. Avoid or Use Alternate Drug. Adverse pregnancy outcomes associated with IDA include increased risk for preterm delivery and low birth weight. Administer on 5 different occasions over a 14 day period. Use Caution/Monitor. (See also Notes section. Intravenous iron sucrose for children with iron deficiency anemia: a This drug is available at the lowest co-pay. 1. Serious - Use Alternative (1)iron sucrose decreases levels of levofloxacin by inhibition of GI absorption. ONE DOSE. iron sucrose decreases levels of doxycycline by inhibition of GI absorption. Use Caution/Monitor. calcium gluconate decreases levels of iron sucrose by inhibition of GI absorption. Adult Patients with Non-Dialysis Dependent-Chronic Kidney Disease (NDD-CKD): Administer Venofer 200 mg undiluted as a slow intravenous injection over 2 to 5 minutes or as an infusion of 200 mg in a maximum of 100 mL of 0.9% NaCl x 15 minutes. iron sucrose increases levels of calcium carbonate by enhancing GI absorption. Use Caution/Monitor. The dose of Ferinject is based on calculation of ideal body weight and calculation of iron deficit using the Ganzoni formula. If these effects continue or worsen, tell your doctor.Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Intravenous therapy is preferred for urgent intervention and when oral iron cannot be absorbed or the patient suffers from chronic renal impairment. Use Caution/Monitor. Venofer (iron sucrose) Uses, Dosage, Side Effects - Drugs.com Ferritin and transferrin are also recommended monitoring . Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. All Rights Reserved. In a randomized, open-label, dose-ranging trial for iron maintenance treatment with Venofer in pediatric patients with CKD on stable erythropoietin therapy [see Clinical Studies ( 14.7)], at least one adverse reaction was experienced by 57% (27/47) of the patients receiving Venofer 0.5 mg/kg, 53% (25/47) of the patients receiving Venofer 1 mg . Adult Patients: The most common adverse reactions (2%) include diarrhea, nausea, vomiting, headache, dizziness, hypotension, pruritus, pain in extremity, arthralgia, back pain, muscle cramp, injection site reactions, chest pain and peripheral edema. 1995 Mar-Apr;11(2):163-8. Indicated for treatment of iron deficiency anemia associated with chronic kidney disease, Hemodialysis-dependent CKD: 100 mg elemental iron IV (injection or infusion over 2-5 min) per dialysis session not to exceed total cumulative dose of 1000 mg divided in 3 doses/week, Non-dialysis-dependent CKD: 200 mg IV injection for 5 doses in over 14 days (cumulative 1000 mg in 14-day period), Peritoneal dialysis-dependent CKD: 300 mg IV infusion (1.5 hr) for 2 doses 14 days apart, THEN 400 mg IV infusion (2.5 hr) 14 days later (cumulative 1000 mg divided in 3 doses/week), Indicated for maintenance treatment of iron-deficient anemia associated with chronic kidney disease, <2 years: Safety and efficacy not established, Iron replacement treatment in pediatric patients has not been established. For adult CKD patients on ESA therapy who are not receiving iron supplementation, the guideline suggests a trial of IV iron (or in NDD-CKD patients, alternatively, a 1- to 3-month trial of oral iron therapy) if: CKD=chronic kidney disease ESA=erythropoietin-stimulating agent Hb=hemoglobin IV=intravenous RBC=red blood cell WBC=white blood cell. Indications: Feraheme is indicated for the treatment of iron deficiency anemia (IDA) in adult patients: who have intolerance to oral iron or have had unsatisfactory response to oral iron or who have chronic kidney disease (CKD). Assessing new treatment options, Intravenous iron-dextran: therapeutic and experimental possibilities. deferasirox decreases levels of iron sucrose by inhibition of GI absorption. The two formulas used are presented below: Iron deficit in mg = Weight in kg x (14 Hb in g/dL) x 2.145, Volume of product required in mL = Iron deficit in mg / C in mg/mL. All you have to do is use the following formula: Liquid\ dose = Dose / Medicine\ concentration Liquid dose = Dose/M edicine concentration. Contraindicated. IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.In Canada - Call your doctor for medical advice about side effects. This cost includes the fee charged by the pharmacy. Avoid or Use Alternate Drug. Use Caution/Monitor. Oral iron therapy is the first method while IV therapy comes in place when there are contraindications or the body doesnt respond to the oral one. Applies only to oral form of both agents. By taking into account the case of a patient weighing 78 kg (172 lbs) and having a hemoglobin level of 11 g/dL (110 g/L or 6.83 mmol/L). Get in touch with MDApp by using the following contact details: 2017 - 2023 MDApp. and formulary information changes. Here are the steps to follow for using this drug dosage calculator: First, enter the value of your Weight and choose the unit of measurement from the drop-down menu. 1988 May;111(5):566-70. Coadministration of ciprofloxacin with multivalent cation-containing products may reduce the bioavailability of ciprofloxacin by 90%.